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Photosensitivity induced by quinidine sulfate: Experimental reproduction of skin lesions
Department of Dermatology, Allergology and Environmental Medicine, HELIOS Klinikum Wuppertal, University of Witten-Herdecke, Germany
A case of quinidine sulfate-induced photodermatitis is presented. The photosensitivity reaction to quinidine sulfate was reproducible in the photopatch test and after oral intake subsequent to UVA irradiation. Eczematous dermatitis was provoked by intradermal injection of in vitro UVA-irradiated quinidine sulfate only in the presence of the patient's serum. Clinical picture and histology suggest an allergic reaction.
The photobinding of quinidine sulfate to a potential carrier protein in skin or serum seems to be of crucial importance to this type of photodermatitis. Quinidine sulfate is frequently used as antiarrhythmic drug. Its potential as photosensitizer should be carefully considered.
© Percy Lehmann (text) and Radoslaw Spiewak (source code).
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Document created: 30 August 2009, last updated: 31 August 2009.